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CSTEAM Biotechnology: Driving Innovation in Life Sciences

 

CSTEAM Biotechnology is an innovative biotech company headquartered in Ohio, USA, dedicated to providing cutting-edge technology solutions for precision medicine. Leveraging its proprietary intellectual property as its core competitiveness, the company focuses on three key R&D areas: functional biological models (such as organoid models, particularly brain organoid models related to neurological diseases), intelligent biochip platforms (including lab-on-a-chip and exosome analysis chips related to neurological diseases), and dual-target CAR-T cell therapies for hematological malignancies. Our products are widely used in drug discovery and screening, mechanism research, personalized diagnosis and treatment, and immune cell therapy development for neurological diseases, demonstrating strong potential in the diagnosis and treatment of major diseases such as neurological diseases and multiple myeloma. Leveraging interdisciplinary integration and international collaboration, CSTEAM is building a comprehensive technology pipeline from basic research to clinical translation, striving to lead the development of next-generation precision medicine technologies. Lab-on-a-Chips, Organoids, Exosomes, RNAs

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Products and Services 

1. Functional Bio-Models

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  • Concept
    Functional organoid models are based on stem cells (embryonic stem cells or induced pluripotent stem cells) or primary cells. Through self-organization and differentiation in a 3D culture system, they form miniature 3D tissues with organ-like structure, cellular diversity, and partial physiological functions. "Organoid" emphasizes similarities to real human organs in morphology, molecular lineage, and function. "Functional" refers to not only cellular diversity but also the ability to reproduce key physiological functions in metabolism, signaling, electrophysiology, or secretion.

  • Functions
    1. Structural Simulation
    2. Cellular Diversity
    3. Functional Response
    4. Disease Recapitulation
    5. Scalability and Operability

  • Applications
    1. Disease Modeling
    2. Drug Discovery
    3. Regenerative Medicine
    4. Mechanistic Research
    5. Technology Platform Integration

2. Intelligent Bio-Chips

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  • Concept
    Smart biochips are advanced platforms that integrate microfluidics, biosensors, artificial intelligence algorithms, and multi-omics data integration. They can simulate and manipulate complex biological processes in microscale environments, reconstructing the functions of cells, tissues, organoids, and entire systems. Compared to traditional biochips, their "intelligence" lies in: dynamic sensing and feedback (sensors monitor physiological parameters in real time); adaptive control (AI adjusts culture fluid flow rate, temperature, nutrient concentration, etc.); and data-driven decision-making (leveraging big data and machine learning for pattern recognition, prediction, and optimization).

  • Functions
    1. High-throughput analysis
    2. Multidimensional monitoring and feedback
    3. Physiological function replication
    4. AI-driven prediction and optimization
    5. Miniaturization and portability

  • Applications
    1. Precision medicine
    2. New drug development
    3. Disease mechanism research
    4. Regenerative medicine and tissue engineering
    5. Public health and environmental monitoring
    6. AI-based medical education and research

3. Dual-target CAR-T Cells

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  • Concept
    Dual-target CAR-T cell therapy integrates two specific single-chain antibody (scFv) recognition structures into a single CAR construct, enabling T cells to simultaneously recognize and target two tumor-associated antigens (such as CD38 and BCMA). This overcomes the tumor escape mechanisms of single-target therapy and improves the efficacy and specificity of tumor treatment.

  • Functions
    1. Enhanced targeting capability
    2. Improved killing efficiency
    3. Improved safety
    4. Inhibition of tumor recurrence

  • Applications
    1. Multiple myeloma
    2. Acute leukemia and lymphoma
    3. Solid tumors
    4. Drug-resistant tumors

Blue Flowers
Human Cell Atlas

We are excited to announce that CSTEAM biotechnology has been officially recognized by the HCA Executive Office as a member of the prestigious Human Cell Atlas (HCA) program! This recognition marks a major milestone for our team as we join a global initiative dedicated to mapping every cell in the human body to advance our understanding of health and disease.

As part of our contribution to the HCA program, CSTEAM biotechnology will focus on developing innovative devices that model the complex interactions between cells and between cells and their surrounding environment. These cutting-edge technologies will play a key role in supporting the HCA's mission to create a comprehensive cellular reference atlas, driving breakthroughs in biomedical research and personalized medicine.

We are honored to be a part of this revolutionary project and look forward to working with the global HCA community to push the boundaries of science.

Haftone Background
Human Cell Atlas in Organs
Human Cell Classification

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